Protein Details: Aquaporin-1

Protein ID

ICDB_Pro_0626

Protein Name

Aquaporin-1

Gene Name

AQP1

Organism

Ovis aries (Sheep)

Length

272 amino acids

AlphaFoldDB

AF-P56401-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water; thereby permitting water to move in the direction of an osmotic gradient. Component of the ankyrin-1 complex; a multiprotein complex involved in the stability and shape of the erythrocyte membrane.

Sequence

MASEFKKKLFWRAVVAEFLAMILFIFISIGSALGFHYPIKSNQTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAIMYIIAQCVGAIVATVILSGITSSLPDNSLGLNALAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRRDLGDSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 58: "Substrate discrimination"; SITE 183: "Substrate discrimination"; SITE 192: "Hg(2+)-sensitive residue"; SITE 198: "Substrate discrimination";

Disease

Location

Detected in fetal kidney (at protein level). Detected in fetal kidney.

DOI ID

10.1007/s004670050502

RefSeq

NP_001009194.1